RalA requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: involvement of metalloproteases.

doi:10.1038/sj.onc.1202850

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Article

RalA requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: involvement of metalloproteases.

Oncogene - 19 Aug 1999

Aguirre-Ghiso J A, Frankel P, Farias E F, Lu Z, Jiang H, Olsen A, Feig L A, de Kier Joffe E B, Foster D A

Abstract excerpt

Overproduction of urokinase-type plasminogen activator (uPA) and metalloproteases (MMPs) is strongly correlated with tumorigenicity and with invasive and metastatic phenotypes of human and experimental tumors. We demonstrated previously that overproduction of uPA in tumor cells is mediated by a phospholipase D (PLD)- and protein kinase C-dependent mechanism. The oncogenic stimulus of v-Src and v-Ras results in...

Topics

3T3 Cells
Animals
Cell Transformation, Neoplastic
Collagenases
GTP Phosphohydrolases
Gelatinases
Gene Expression Regulation, Neoplastic
Genes, ras
Genes, src
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Metalloendopeptidases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred BALB C

Mutation

Up-Regulation

Urokinase-Type Plasminogen Activator

ral GTP-Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 10467419
DOI: 10.1038/sj.onc.1202850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.