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Article

Spontaneous transformation of an immortalized hepatocyte cell line: potential role of a nuclear protease.

Cancer letters - 15 Sept 2004

Drubin David A, Clawson Gary A

Abstract excerpt

In this study, we utilized an in vitro model of spontaneous transformation/progression, an SV40 large T antigen-immortalized rat hepatocyte cell line (designated CWSV14) that is very weakly tumorigenic at low-passage, but acquires a transformed phenotype upon extended passage in cell culture. Here we show that this mid-passage transformation is accompanied by development of aneuploidy and disorganization of the...

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Identifiers

PMID: 15312682
DOI: 10.1016/j.canlet.2004.03.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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