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Article

Deregulation of the signaling pathways controlling urokinase production

15 Jul 1999

Abstract excerpt

We review the evidence in support of the notion that, upon experimental oncogenic transformation or in spontaneous human cancers, mitogenesis and expression of urokinase (uPA) and its receptor (uPAR) are activated through common signaling complexes and pathways. It is well documented that uPA, uPAR or metalloproteinases (MMPs) are overexpressed in tumor cells of mesenchymal or epithelial origin and these...

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PMID: 10406935
DOI: 10.1046/j.1432-1327.1999.00507.x

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