v-Ha-Ras insertion/deletion mutants with reduced protease-inhibitory activity have no transforming activity.

doi:10.1016/0014-5793(93)80532-y

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Article

v-Ha-Ras insertion/deletion mutants with reduced protease-inhibitory activity have no transforming activity.

FEBS letters - 8 Mar 1993

Sawada T, Sakiyama S, Hiwasa T

Abstract excerpt

We have purified 26 insertion/deletion mutants of v-Ha-ras oncogene products produced by Escherichia coli and investigated their protease-inhibitory activity toward papain and cathepsins B and L. Ki values for papain were relatively similar among the mutants, however, those for cathepsins B and L...

Topics

3T3 Cells
Animals
Cathepsin B
Cathepsin L
Cathepsins
Cell Transformation, Neoplastic
Cysteine Endopeptidases
Endopeptidases
Escherichia coli
Gene Deletion
Genes, ras
Mice
Mutation
Papain
Protease Inhibitors
Structure-Activity Relationship

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