Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts.

doi:10.1074/jbc.274.2.801

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Article

Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts.

The Journal of biological chemistry - 8 Jan 1999

Janulis M, Silberman S, Ambegaokar A, Gutkind J S, Schultz R M

Abstract excerpt

Ras activates a multitude of downstream activities with roles in cellular proliferation, invasion and metastasis, differentiation, and programmed cell death. In this work we have evaluated the requirement of extracellular signal-regulated protein kinase (ERK), c-Jun NH2-terminal kinase kinase (JN...

Topics

3T3 Cells
Animals
Anisomycin
Basement Membrane
Calcium-Calmodulin-Dependent Protein Kinases
Carbachol
Cathepsin L
Cathepsins
Cell Transformation, Neoplastic
Cysteine Endopeptidases
Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Enzyme Activation

Genes, ras

Mice

Mutation

Neoplasm Invasiveness

Phenotype

Platelet-Derived Growth Factor

Source

Open in PubMed

Identifiers

PMID: 9873019
DOI: 10.1074/jbc.274.2.801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9873019-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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