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Article

Constitutive expression and secretion of proteases in non-metastatic SP1 mammary carcinoma cells and its metastatic sublines.

International journal of cancer - 19 Jun 1991

Korczak B, Kerbel R S, Dennis J

Abstract excerpt

Malignant tumors are generally characterized by extensive local tissue invasion and destruction of ECM which may be due to increased constitutive expression and activity of secreted proteases. Moreover, a large number of diverse protease activities may be constitutively over-expressed in a simultaneous or co-ordinated fashion, thereby significantly increasing cellular invasive potential of the cells. To explore...

Topics

Adenocarcinoma
Animals
Cell Line
Endopeptidases
Genetic Variation
Kinetics
Mammary Neoplasms, Experimental
Mice
Neoplasm Metastasis
Plasminogen Activators
RNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription, Genetic

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Identifiers

PMID: 2045200
DOI: 10.1002/ijc.2910480413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2045200-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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