Article
Characterization of downstream Ras signals that induce alternative protease-dependent invasive phenotypes.
The Journal of biological chemistry - 28 Feb 1997
Silberman S, Janulis M, Schultz R M
Abstract excerpt
Invasive and metastatic cells require protease expression for migration through the extracellular matrix. Metastatic NIH 3T3 fibroblasts transformed by different activated ras genes showed two different protease phenotypes, rasuPA+/CL- and rasCL+/uPA- (Zhang, J-Y., and Schultz, R. M. (1992) Cance...
Topics
- 3T3 Cells
- Animals
- Blotting, Western
- Calcium-Calmodulin-Dependent Protein Kinases
- Endopeptidases
- Fibroblasts
- Genes, ras
- Humans
- Mice
- Models, Biological
- Phenotype
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-jun
- Signal Transduction