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Article

Characterization of downstream Ras signals that induce alternative protease-dependent invasive phenotypes.

The Journal of biological chemistry - 28 Feb 1997

Silberman S, Janulis M, Schultz R M

Abstract excerpt

Invasive and metastatic cells require protease expression for migration through the extracellular matrix. Metastatic NIH 3T3 fibroblasts transformed by different activated ras genes showed two different protease phenotypes, rasuPA+/CL- and rasCL+/uPA- (Zhang, J-Y., and Schultz, R. M. (1992) Cancer Research 52, 6682-6689). Phenotype rasuPA+/CL- is dependent on expression of the serine-type protease urokinase...

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PMID: 9038212
DOI: 10.1074/jbc.272.9.5927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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