Article
Expression of human O6-methylguanine-DNA methyltransferase in a DNA excision repair-deficient Chinese hamster ovary cell line and its response to certain alkylating agents.
Cancer research - 1 Jan 1992
Wu Z N, Chan C L, Eastman A, Bresnick E
Abstract excerpt
A plasmid has been constructed in which the expression of human O6-methylguanine-DNA methyltransferase (MGMT) complementary DNA is driven by the Rous sarcoma virus promoter sequence. We had previously shown that transfection of this plasmid into Chinese hamster ovary (CHO) cells results in the ex...
Topics
- Animals
- CHO Cells
- Cell Line
- Cricetinae
- DNA
- DNA Repair
- Ethylnitrosourea
- Humans
- Methylnitronitrosoguanidine
- Methyltransferases
- O(6)-Methylguanine-DNA Methyltransferase
- Phenotype
- Transfection