Article
Mutations and epimutations in mammalian cells.
Mutation research - 1 Jan 2000
Holliday R
Abstract excerpt
Early studies on heritable variation in cultured mammalian cells suggested that both mutation and epigenetic events might be involved. The importance of mutations has subsequently been fully documented, but only recently has an alternative form of inheritance been uncovered. This is based on the post-synthetic methylation of cytosine in regulatory regions of genes. The pattern of methylation is heritable, and in...
Topics
- Animals
- Cell Differentiation
- Cell Transformation, Neoplastic
- Cells, Cultured
- DNA
- Genetic Variation
- Humans
- Mammals
- Methylation
- Mutation