Article
Expression of the human MGMT O6-methylguanine DNA methyltransferase gene in a yeast alkylation-sensitive mutant: its effects on both exogenous and endogenous DNA alkylation damage.
Mutation research - 1 Mar 1995
Xiao W, Fontanie T
Abstract excerpt
Common Mer- cell lines deficient in O6-methylguanine DNA methyltransferase (MTase) activity probably result from the down-regulation of, rather than mutations in, the MGMT gene. However, the down-regulation of other unrelated genes was also observed in some of these cell lines, making it difficul...
Topics
- Alkylation
- Base Sequence
- Cloning, Molecular
- DNA Damage
- DNA Repair
- Drug Resistance
- Genetic Complementation Test
- Humans
- Methylnitronitrosoguanidine
- Methyltransferases
- Molecular Sequence Data
- Mutagenesis
- Mutation
- O(6)-Methylguanine-DNA Methyltransferase
- Recombinant Proteins
- Saccharomyces cerevisiae