In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

doi:10.1073/pnas.90.6.2117

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Article

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1993

Xiao W, Samson L

Abstract excerpt

Three genes that participate in the repair of DNA alkylation damage were recently cloned from Saccharomyces cerevisiae: the MGT1 O6-methylguanine DNA methyltransferase gene, the MAG 3-methyladenine DNA glycosylase gene, and the APN1 apurinic/apyrimidinic (AP) endonuclease gene. Altering the expre...

Topics

Alkylation
DNA Damage
DNA Glycosylases
DNA Repair
DNA, Fungal
DNA-(Apurinic or Apyrimidinic Site) Lyase
Deoxyribonuclease IV (Phage T4-Induced)
Endodeoxyribonucleases
Gene Expression
Genes, Fungal
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methyl Methanesulfonate

Methylnitronitrosoguanidine

Methyltransferases

Mutation

N-Glycosyl Hydrolases

O(6)-Methylguanine-DNA Methyltransferase

Saccharomyces cerevisiae

Source

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Identifiers

PMID: 7681584
DOI: 10.1073/pnas.90.6.2117
PMCID: PMC46036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7681584-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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