Article
Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents.
Carcinogenesis - 1 Oct 1991
Kaina B, Fritz G, Mitra S, Coquerelle T
Abstract excerpt
O6-Methylguanine-DNA methyltransferase (MGMT) is responsible for removal of O6-alkylguanine from DNA induced by alkylating mutagens/carcinogens. To analyze the involvement of O6-alkylguanine in the generation and MGMT in avoidance of various genotoxic effects of alkylating agents, we transfected...
Topics
- Alkylating Agents
- Animals
- CHO Cells
- Cell Survival
- Chromosome Aberrations
- Clone Cells
- Cricetinae
- DNA
- Gene Expression
- Humans
- Methylnitronitrosoguanidine
- Methyltransferases
- Mutagens
- Mutation
- O(6)-Methylguanine-DNA Methyltransferase