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Article

Defining the nucleic acid substrate for somatic hypermutation.

Immunology and cell biology - 1 Apr 1992

Steele E J, Rothenfluh H S, Both G W

Abstract excerpt

Recent reports have more precisely defined the distribution of somatic mutations around rearranged mouse V-D-J genes. The 5' boundary of mutation is most likely in the region of the transcription start site (cap) and/or the promoter (P), implying that transcription may be a prerequisite for mutations to be generated. As more than 95% of somatic mutations lie downstream of the cap site, the transcription unit...

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Identifiers

PMID: 1398773
DOI: 10.1038/icb.1992.18

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defining the nucleic acid substrate for somatic hypermutation.PMID 1398773Read ↗

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