Article
Defining the nucleic acid substrate for somatic hypermutation.
Immunology and cell biology - 1 Apr 1992
Steele E J, Rothenfluh H S, Both G W
Abstract excerpt
Recent reports have more precisely defined the distribution of somatic mutations around rearranged mouse V-D-J genes. The 5' boundary of mutation is most likely in the region of the transcription start site (cap) and/or the promoter (P), implying that transcription may be a prerequisite for mutat...
Topics
- Animals
- Genes, Immunoglobulin
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Models, Genetic
- Mutation
- Nucleic Acids
- Transcription, Genetic