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Article

The boundaries of the distribution of somatic hypermutation of rearranged immunoglobulin variable genes.

Immunology and cell biology - 1 Apr 2004

Blanden Robert V, Franklin Andrew, Steele Edward J

Abstract excerpt

Available evidence about the mechanisms and distribution of somatic hypermutation (SHM) of rearranged immunoglobulin (IgV) genes is reviewed with particular emphasis on the 5' boundary. In heavy (H) chain genes, the 5' boundary of SHM is the transcription start site; in contrast to kappa light (L) chain genes, it is located in the leader (L) intron. DNA-based models of SHM cannot account for this difference....

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Identifiers

PMID: 15061775
DOI: 10.1046/j.0818-9641.2004.01226.x

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