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Article

Distribution of mutations around rearranged heavy-chain antibody variable-region genes.

Molecular and cellular biology - 1 Oct 1990

Both G W, Taylor L, Pollard J W, Steele E J

Abstract excerpt

The mechanism of somatic hypermutation in the variable region of immunoglobulin genes expressed in mammalian B cells is a major unexplained phenomenon in the generation of diversity in the immune system. To evaluate possible mechanisms, the distribution of somatic mutations was examined for a group of five cloned, rearranged, somatically mutated VH genes generated in C57BL/6j mice. These mutated VH genes were...

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Identifiers

PMID: 2118991
DOI: 10.1128/mcb.10.10.5187-5196.1990
PMCID: PMC361197

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Source receipt: pubmed, retrieved 7 Sept 2026.

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