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Article

The mechanism of somatic hypermutation studied with transgenic and transfected target genes.

Seminars in immunology - 1 Jun 1996

Storb U, Peters A, Klotz E, Rogerson B, Hackett J

Abstract excerpt

Somatic hypermutation of Ig genes is beginning to be understood in molecular terms. Ig transgenes have served as model test genes and been shown to mutate, just as endogenous genes, with a peak of mutation over the VJ region and a sparing of the C region. The levels of somatic mutation appear to be related to the expression of the transgenes. DNA hypermethylation of modified Ig transgenes interferes with both...

Topics

Animals
Base Sequence
Genes, Immunoglobulin
Humans
Mice
Mice, Transgenic
Molecular Sequence Data
Mutation
Receptors, Antigen, T-Cell
Transcription, Genetic
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transgenes

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Identifiers

PMID: 8738912
DOI: 10.1006/smim.1996.0017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8738912-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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