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Article

Somatic hypermutation of immunoglobulin genes.

Annual review of immunology - 1 Jan 1996

Wagner S D, Neuberger M S

Abstract excerpt

The relationship between somatic hypermutation and affinity maturation in the mouse is delineated. Recent work on the anatomical and cellular site of this process is surveyed. The molecular characteristics of somatic hypermutation are described in terms of the region mutated and the distinctive patterns of nucleotide changes that are observed. The results of experiments utilizing transgenic mice to find out the...

Topics

Animals
Genes, Immunoglobulin
Mutation

Source

Identifiers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

PMID: 8962691
DOI: 10.1146/annurev.immunol.14.1.441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8962691-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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