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Article

Expression of the TGF alpha integral membrane precursor induces transformation of NRK cells.

Oncogene - 1 Aug 1990

Blasband A J, Gilligan D M, Winchell L F, Wong S T, Luetteke N C, Rogers K T, Lee D C

Abstract excerpt

TGF alpha is one member of a family of soluble growth factors that are derived from integral-membrane precursors. The mature form of TGF alpha is released from its transmembrane precursor (proTGF alpha) by a protease that, in many tumor cells, is inefficient or limiting. We have previously established that, in the absence of processing, membrane-anchored proTGF alpha is biologically active and can interact with...

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Source

Identifiers

PMID: 2392325

Genes

NRK
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the TGF alpha integral membrane precursor induces transformation of NRK cells.PMID 2392325Read ↗

TGF-alpha: expression and biological activities of the integral membrane precursor.Semantic proximity Read ↗

Role of TGF-beta in EGF-induced transformation of NRK cells is sustaining high-level EGF-signaling.Semantic proximity Read ↗

Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism.Semantic proximity Read ↗

Proteolytic processing of TGFalpha redirects its mitogenic activity: the membrane-anchored form is autocrine, the secreted form is paracrine.Semantic proximity Read ↗

Signal transduction cascade shared by epidermal growth factor and platelet-derived growth factor is a major pathway for oncogenic transformation in NRK cells.Semantic proximity Read ↗

Role of a signal transduction pathway which controls disassembly of microfilament bundles and suppression of high-molecular-weight tropomyosin expression in oncogenic transformation of NRK cells.Semantic proximity Read ↗

Direct transforming activity of TGF-beta on rat fibroblasts.Semantic proximity Read ↗

Cell transformation by kFGF requires secretion but not glycosylation.Semantic proximity Read ↗

Autocrine production of prostaglandin F2alpha enhances phenotypic transformation of normal rat kidney fibroblasts.Semantic proximity Read ↗

Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts.Semantic proximity Read ↗

Phenotypic transformation of normal rat kidney cells by transforming growth factor beta is not paralleled by enhanced production of a platelet-derived growth factor.Semantic proximity Read ↗

Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta.Semantic proximity Read ↗

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