Article
Expression of the TGF alpha integral membrane precursor induces transformation of NRK cells.
Oncogene - 1 Aug 1990
Blasband A J, Gilligan D M, Winchell L F, Wong S T, Luetteke N C, Rogers K T, Lee D C
Abstract excerpt
TGF alpha is one member of a family of soluble growth factors that are derived from integral-membrane precursors. The mature form of TGF alpha is released from its transmembrane precursor (proTGF alpha) by a protease that, in many tumor cells, is inefficient or limiting. We have previously establ...
Topics
- Animals
- Cell Transformation, Neoplastic
- ErbB Receptors
- Kidney
- Membrane Proteins
- Mice
- Mutation
- Protein Precursors
- Rats
- Transforming Growth Factors