Endogenous glutathione levels modulate the frequency of both spontaneous and long wavelength ultraviolet induced mutations in human cells.

doi:10.1093/carcin/13.9.1557

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Article

Endogenous glutathione levels modulate the frequency of both spontaneous and long wavelength ultraviolet induced mutations in human cells.

Carcinogenesis - 1 Sept 1992

Applegate L A, Lautier D, Frenk E, Tyrrell R M

Abstract excerpt

Spontaneous and induced mutations at the hypoxanthine guanine phosphoribosyl transferase locus have been measured in cultured human lymphoblastoid (TK6) cell populations under conditions in which cellular glutathione has been severely depleted by overnight treatment with buthionine-S,R-sulfoximin...

Topics

Buthionine Sulfoximine
Cells, Cultured
Glutathione
Humans
Hypoxanthine Phosphoribosyltransferase
Methionine Sulfoximine
Mutation
Radiation-Sensitizing Agents
Ultraviolet Rays

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