Somatic gene mutations in vivo as indicated by the 6-thioguanine-resistant T-lymphocytes in human blood.

doi:10.1016/0027-5107(85)90138-1

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Article

Somatic gene mutations in vivo as indicated by the 6-thioguanine-resistant T-lymphocytes in human blood.

Mutation research - 1 Jan 2000

Albertini R J

Abstract excerpt

The clonal and the autoradiographic assays for 6-thioguanine-resistant (TGr) T-lymphocytes (T-Lys) in human blood are reviewed. Studies of TGr colonies recovered from clonal assays show that the mutant T-Lys (i) are either helper (T4) or suppressor (T8) cells, (ii) possess stable TGr phenotypes,...

Topics

Adult
Cells, Cultured
Drug Resistance
Genes
Humans
Hypoxanthine Phosphoribosyltransferase
Mutagenicity Tests
Mutation
T-Lymphocytes
Thioguanine

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