Article
Radiation-induced long-lived radicals which cause mutation and transformation.
Mutation research - 12 Oct 1998
Koyama S, Kodama S, Suzuki K, Matsumoto T, Miyazaki T, Watanabe M
Abstract excerpt
Using electronic spin resonance (ESR), we found a new type of radical with a long life-time in cells (T1/2>20 h) and which may play a more important role in the induction of mutation and transformation than either the active, short-lived, H, or OH radicals. When cells were treated with dimethyl s...
Topics
- Animals
- Ascorbic Acid
- Cell Line
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Dimethyl Sulfoxide
- Electron Spin Resonance Spectroscopy
- Free Radical Scavengers
- Free Radicals
- Half-Life
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Mice
- Mutation
- Radiation Tolerance