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Article

High level glucose increases mutagenesis in human lymphoblastoid cells

1 Jan 2007

Abstract excerpt

Epidemiological data have suggested an increased cancer rates in diabetic patients, for which the underlying mechanism is poorly understood. We studied whether high level of glucose (HG) treatment that mimic the hyperglycemic condition in diabetes mellitus is mutagenic. Mutagenesis studies were carried out at both hypoxanthine phosphoribosyltransferase (hprt) and thymidine kinase (tk) loci. Role of p53 in...

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PMID: 17848982
DOI: 10.7150/ijbs.3.375

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