Article
cis-dominant defect in activation of adenovirus type 5 E1b early RNA synthesis.
Journal of virology - 1 Jun 1990
Parks C L, Spector D J
Abstract excerpt
A cis-dominant mutation in the adjacent E1a gene disrupted the accumulation of adenovirus type 5 E1b mRNA during the early phase of infection. Steady-state levels of cytoplasmic and nuclear E1b RNAs in cells infected with dl312, a strain that lacks the E1a TATA box, cap site, and much of the coding sequence, were reduced 5- to 10-fold even when the E1a activator was provided in trans. The strain was defective for...
Topics
- Adenovirus Early Proteins
- Cell Nucleus
- Gene Expression Regulation, Viral
- Genes, Dominant
- Genes, Viral
- Humans
- KB Cells
- Mutation
- Oncogene Proteins, Viral
- Promoter Regions, Genetic
- RNA, Messenger