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Article

Adenovirus type 12 early region 1B proteins and metabolism of early viral mRNAs.

Virology - 1 Dec 1992

Zhang S, Mak S, Branton P E

Abstract excerpt

Early region 1B (E1B) of human adenoviruses encodes two major proteins. The 19-kDa polypeptide appears to prevent E1A-induced cytolysis and DNA degradation. The larger E1B product of approximately 55 kDa, which is essential for viral replication, plays a role in the accumulation and stability of viral mRNAs and the late shutoff of host metabolism. For serotype 12 (Ad12), this 482-residue (482R) protein is...

Topics

Adenovirus E1B Proteins
Adenovirus E2 Proteins
Adenovirus E3 Proteins
Adenovirus E4 Proteins
Adenoviruses, Human
Cell Nucleus
Cells, Cultured
Cytoplasm
DNA Mutational Analysis
DNA, Viral
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Phenotype

RNA, Messenger

Source

Identifiers

PMID: 1448923
DOI: 10.1016/0042-6822(92)90255-n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1448923-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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