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Article

Breast cancer is associated with loss of the c‐<i>kit</i> oncogene product

11 Nov 1992

Abstract excerpt

The proto-oncogene c-kit encodes a tyrosine kinase receptor related to the PDGF/CSF-1 receptors. Mutations of this gene result in impairment of hematopoiesis, melanogenesis and gametogenesis. Using monoclonal antibodies to the c-kit gene product, we have analyzed its expression in normal and transformed human tissues. Unexpectedly, the receptor was found to be expressed in normal mammary epithelium. While in...

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Identifiers

PMID: 1385336
DOI: 10.1002/ijc.2910520508

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Related research

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Research trail→

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Breast cancer is associated with loss of the c‐<i>kit</i> oncogene productPMID 1385336Read ↗

Progression of human cutaneous melanoma is associated with loss of expression of c<i>‐kit</i> proto‐oncogene receptorSemantic proximity Read ↗

c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer.Semantic proximity Read ↗

The receptor encoded by the human C‐<i>MET</i> oncogene is expressed in hepatocytes, epithelial cells and solid tumorsSemantic proximity Read ↗

Amplification and Overexpression of the <i>KIT</i> Gene Is Associated with Progression in the Seminoma Subtype of Testicular Germ Cell Tumors of Adolescents and AdultsSemantic proximity Read ↗

Differential expression of the c‐<i>kit</i> proto‐oncogene in germ cell tumoursSemantic proximity Read ↗

Characterization of the Promoter Region of the Human c‐<i>kit</i> Proto‐oncogeneSemantic proximity Read ↗

Expression of proto-oncogene KIT is up-regulated in subset of human meningiomas.Semantic proximity Read ↗

Loss of c-met protooncogene in primary and metastatic sites of breast cancer.Semantic proximity Read ↗

Identification of the c-kit gene mutations in biopsy tissues of mammary gland carcinoma tumor.Semantic proximity Read ↗

Developmental expression of c-kit, a proto-oncogene encoded by the W locus.Semantic proximity Read ↗

Expression of isoforms of the human receptor tyrosine kinase c-kit in leukemic cell lines and acute myeloid leukemiaSemantic proximity Read ↗

Structural organization of the murine c-kit proto-oncogene.Semantic proximity Read ↗

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