Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer.

Oncogene - 16 Feb 2012

Regan J L, Kendrick H, Magnay F-A, Vafaizadeh V, Groner B, Smalley M J

Abstract excerpt

BRCA1 mutation-associated breast cancer originates in oestrogen receptor-alpha-negative (ER(-)) progenitors in the mammary luminal epithelium. These cells also express high levels of the Kit gene and a recent study demonstrated a correlation between Brca1 loss and Kit over-expression in the mammary epithelium. However, the functional significance of c-Kit expression in the mammary gland is unknown. To address...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to Epithelial Cells
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

Share to Mammary Neoplasms, Experimental

Share to NIH 3T3 Cells

Share to Proto-Oncogene Proteins c-kit

Share to Stem Cells

Source

Identifiers

PMID: 21765473
DOI: 10.1038/onc.2011.289

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer.PMID 21765473Read ↗

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.Semantic proximity Read ↗

Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland.Semantic proximity Read ↗

A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase.Semantic proximity Read ↗

Luminal progenitors restrict their lineage potential during mammary gland development.Semantic proximity Read ↗

Detection and analysis of mammary gland stem cellsSemantic proximity Read ↗

CCAAT/Enhancer Binding Protein Beta Regulates Stem Cell Activity and Specifies Luminal Cell Fate in the Mammary GlandSemantic proximity Read ↗

Somatic loss of p53 leads to stem/progenitor cell amplification in both mammary epithelial compartments, basal and luminalSemantic proximity Read ↗

AXL Is a Driver of Stemness in Normal Mammary Gland and Breast CancerSemantic proximity Read ↗

Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.Semantic proximity Read ↗

BRCA1--conductor of the breast stem cell orchestra: the role of BRCA1 in mammary gland development and identification of cell of origin of BRCA1 mutant breast cancer.Semantic proximity Read ↗

p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic ValueSemantic proximity Read ↗

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.