Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progression of human cutaneous melanoma is associated with loss of expression of c<i>‐kit</i> proto‐oncogene receptor

9 Sept 1992

Abstract excerpt

Mutations at the white spotting (w) locus in mice have deleterious effects on germ cells, melanocytes and hematopoietic stem cells. The w locus encodes the c-kit tyrosine-kinase receptor whose ligand is the product of the SI locus. Using monoclonal antibodies (MAb(s)) to the extracellular domain, we have evaluated the expression of c-kit in normal and transformed melanocytes. This cell lineage synthesizes a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cutaneous Melanoma Detection and Management
Share to melanin and skin pigmentation
Share to Melanoma and MAPK Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1381702
DOI: 10.1002/ijc.2910520207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progression of human cutaneous melanoma is associated with loss of expression of c<i>‐kit</i> proto‐oncogene receptorPMID 1381702Read ↗

Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.Semantic proximity Read ↗

Ectopic expression of a c-kitW42 minigene in transgenic mice: recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors.Semantic proximity Read ↗

Breast cancer is associated with loss of the c‐<i>kit</i> oncogene productSemantic proximity Read ↗

Differential effects of W mutations on p145c-kit tyrosine kinase activity and substrate interaction.Semantic proximity Read ↗

Conditional Deletion of Kit in Melanocytes: White Spotting Phenotype Is Cell Autonomous.Semantic proximity Read ↗

Instability at the W/c-kit locus in mice: analysis of melanocyte cell lines derived from reversion spots.Semantic proximity Read ↗

The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase.Semantic proximity Read ↗

recessive spotting: a linked locus that interacts with W/Kit but is not allelic.Semantic proximity Read ↗

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.Semantic proximity Read ↗

The murine W/c-kit and Steel loci and the control of hematopoiesis.Semantic proximity Read ↗

Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.