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Article

Identification of the c-kit gene mutations in biopsy tissues of mammary gland carcinoma tumor.

Journal of the Egyptian National Cancer Institute - 1 Jun 2012

Hussain Syed Rizwan, Naqvi Hena, Ahmed Faisal, Babu Sunil G, Bansal Cherry, Mahdi Farzana

Abstract excerpt

C-kit gene is a transmembrane tyrosine kinase that acts as type III receptor for mast cell growth factor and cellular migration, proliferation, survival of melanoblasts, haematopoietic progenitors and primordial germ cells. Apart from the scant information about the pathologies associated with loss-of-function mutations, few reports have proposed role of the c-kit gene in case of carcinogenesis. Apparently, in...

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PMID: 23582602
DOI: 10.1016/j.jnci.2011.10.003

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