Article
Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.
The Journal of cell biology - 1 Jun 1994
Riberdy J M, Avva R R, Geuze H J, Cresswell P
Abstract excerpt
We have compared the intracellular transport and subcellular distribution of MHC class II-invariant chain complexes in a wild-type HLA-DR3 homozygous cell line and a mutant cell line, T2.DR3. The latter has a defect in antigen processing and accumulates HLA-DR3 molecules associated with an invari...
Topics
- Antigen Presentation
- Antigens, Differentiation, B-Lymphocyte
- B-Lymphocytes
- Biological Transport
- Biomarkers
- Cell Line
- Endocytosis
- Frozen Sections
- HLA-DR3 Antigen
- Histocompatibility Antigens Class II
- Homozygote
- Humans
- Immunohistochemistry
- Microscopy, Immunoelectron
- Mutation
- Peptide Fragments