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Article

Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.

The Journal of cell biology - 1 Jun 1994

Riberdy J M, Avva R R, Geuze H J, Cresswell P

Abstract excerpt

We have compared the intracellular transport and subcellular distribution of MHC class II-invariant chain complexes in a wild-type HLA-DR3 homozygous cell line and a mutant cell line, T2.DR3. The latter has a defect in antigen processing and accumulates HLA-DR3 molecules associated with an invariant chain-derived peptide (CLIP) rather than the normal complement of peptides derived from endocytosed proteins. We...

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Identifiers

PMID: 8207055
DOI: 10.1083/jcb.125.6.1225
PMCID: PMC2290929

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.PMID 8207055Read ↗

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