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Article

Attenuation of IL-7 receptor signaling is not required for allelic exclusion.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2006

Will Wynette M, Aaker Joshua D, Burchill Matthew A, Harmon Ian R, O'Neil Jennifer J, Goetz Christine A, Hippen Keli L, Farrar Michael A

Abstract excerpt

Allelic exclusion prevents pre-B cells from generating more than one functional H chain, thereby ensuring the formation of a unique pre-BCR. The signaling processes underlying allelic exclusion are not clearly understood. IL-7R-dependent signals have been clearly shown to regulate the accessibility of the Ig H chain locus. More recent work has suggested that pre-BCR-dependent attenuation of IL-7R signaling...

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Identifiers

PMID: 16517702
DOI: 10.4049/jimmunol.176.6.3350

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Attenuation of IL-7 receptor signaling is not required for allelic exclusion.PMID 16517702Read ↗

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