Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acquisition of a tumorigenic phenotype by a rat ventral prostate epithelial cell line expressing a transfected activated neu oncogene.

Cancer research - 1 Jun 1992

Sikes R A, Chung L W

Abstract excerpt

The neu oncogene has been demonstrated to be a potent transforming gene in rodent fibroblasts. The overexpression of the human erbB-2/neu oncogene has been implicated in the development and/or prognosis of several human carcinomas including that of the prostate. To assess the transforming potential of the activated rat neu oncogene in prostatic epithelial carcinogenesis, this laboratory has transfected a cloned...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Blotting, Southern
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Molecular Sequence Data

Share to Phenotype

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 1350510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acquisition of a tumorigenic phenotype by a rat ventral prostate epithelial cell line expressing a transfected activated neu oncogene.PMID 1350510Read ↗

Overexpression of activated neu/erbB2 initiates immortalization and malignant transformation of immature Schwann cells in vitro.Semantic proximity Read ↗

Polymorphic changes of cell phenotype caused by elevated expression of an exogenous NEU proto-oncogene.Semantic proximity Read ↗

Partial reversion of transformed phenotype of B104 cancer cells by antisense nucleic acids.Semantic proximity Read ↗

Negative regulation of the neu promoter by the SV40 large T antigen.Semantic proximity Read ↗

Point mutation of the neu gene in rat neural tumor RT4-AC cells: suppression of tumorigenicity by s-Myc.Semantic proximity Read ↗

Transfection of rat ovarian surface epithelium with erb-B2/neu induces transformed phenotypes in vitro and the tumorigenic phenotype in vivo.Semantic proximity Read ↗

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.Semantic proximity Read ↗

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.Semantic proximity Read ↗

The induction of apoptosis in human mammary luminal epithelial cells by expression of activated c-neu and its abrogation by glucocorticoids.Semantic proximity Read ↗

Kinase-deficient neu proteins suppress epidermal growth factor receptor function and abolish cell transformation.Semantic proximity Read ↗

Metastasis induced by overexpression of p185neu-T after orthotopic injection into a prostatic epithelial cell line (NbE).Semantic proximity Read ↗

Wild type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.