Transfection of rat ovarian surface epithelium with erb-B2/neu induces transformed phenotypes in vitro and the tumorigenic phenotype in vivo.

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Article

Transfection of rat ovarian surface epithelium with erb-B2/neu induces transformed phenotypes in vitro and the tumorigenic phenotype in vivo.

The American journal of pathology - 1 Jan 1998

Davies B R, Auersperg N, Worsley S D, Ponder B A

Abstract excerpt

The neu/cerb-B2 gene is frequently amplified and/or overexpressed in human epithelial ovarian cancers. We have established an inbred animal model for ovarian cancer that mimics aspects of human ovarian cancer by transducing a spontaneously immortalized rat ovarian surface epithelial cell line in...

Topics

Animals
Cell Division
Cell Transformation, Neoplastic
Collagen
Cytological Techniques
Drug Combinations
Epithelium
Female
Genes, erbB-2
Immunohistochemistry
Laminin
Neoplasm Invasiveness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Transplantation

Ovary

Peritoneal Neoplasms

Phenotype

Proteoglycans

Rats

Source

Open in PubMed Open full text

Identifiers

PMID: 9422547
PMCID: PMC1858128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9422547-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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