Partial reversion of transformed phenotype of B104 cancer cells by antisense nucleic acids.

doi:10.1016/0304-3835(93)90028-8

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Article

Partial reversion of transformed phenotype of B104 cancer cells by antisense nucleic acids.

Cancer letters - 15 Apr 1993

Shaw Y T, Chang S H, Chiou S T, Chang W C, Lai M D

Abstract excerpt

We used antisense RNA to inhibit the expression of oncogene neu and investigated the effects of diminished neu expression on the phenotypes of B104 cells containing activated oncogene neu. Antisense MT-neu and pSV-neo plasmids were cotransfected into neuroblastoma B104 cells. Southern analysis sh...

Topics

Animals
Cell Transformation, Neoplastic
Gene Expression
Neuroblastoma
Oncogenes
Phenotype
Proto-Oncogene Proteins
RNA, Antisense
Rats
Receptor, ErbB-2
Transfection
Tumor Cells, Cultured

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