Article

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.

1994-11-01

Abstract excerpt

Amplification of the Neu/c-erbB-2 receptor tyrosine kinase has been implicated as an important event in the genesis of human breast cancer. Indeed, transgenic mice bearing either an activated form of neu or the wild-type proto-oncogene under the transcriptional control of the mouse mammary tumor virus promoter-enhancer frequently develop mammary carcinomas (L. Bouchard, L. Lamarre, P. J. Tremblay, and P. Jolicoeur...

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Literature Corpus work: 8cbfb69e-8e65-5374-9a66-73b5d0480da3
DOI: 10.1128/mcb.14.11.7068

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