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Article

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.

Molecular and cellular biology - 1 Nov 1994

Siegel P M, Dankort D L, Hardy W R, Muller W J

Abstract excerpt

Amplification of the Neu/c-erbB-2 receptor tyrosine kinase has been implicated as an important event in the genesis of human breast cancer. Indeed, transgenic mice bearing either an activated form of neu or the wild-type proto-oncogene under the transcriptional control of the mouse mammary tumor virus promoter-enhancer frequently develop mammary carcinomas (L. Bouchard, L. Lamarre, P. J. Tremblay, and P....

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Identifiers

PMID: 7935422
DOI: 10.1128/mcb.14.11.7068-7077.1994
PMCID: PMC359240

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.PMID 7935422Read ↗

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.Semantic proximity Read ↗

Oncogenic activating mutations in the neu/erbB-2 oncogene are involved in the induction of mammary tumors.Semantic proximity Read ↗

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Agonistic antibodies stimulate the kinase encoded by the neu protooncogene in living cells but the oncogenic mutant is constitutively active.Semantic proximity Read ↗

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