Article
Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.
Molecular and cellular biology - 1 Nov 1994
Siegel P M, Dankort D L, Hardy W R, Muller W J
Abstract excerpt
Amplification of the Neu/c-erbB-2 receptor tyrosine kinase has been implicated as an important event in the genesis of human breast cancer. Indeed, transgenic mice bearing either an activated form of neu or the wild-type proto-oncogene under the transcriptional control of the mouse mammary tumor...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- DNA Primers
- DNA, Neoplasm
- Gene Expression Regulation, Neoplastic
- Genes, erbB-2
- Humans
- Mammary Neoplasms, Experimental
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Proto-Oncogene Mas
- Rats
- Receptor, ErbB-2