Article
Wild type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells.
Oncogene - 21 Mar 1996
Nikitin A Y, Jin J J, Papewalis J, Prokopenko S N, Pozharisski K M, Winterhager E, Flesken-Nikitin A, Rajewsky M F
Abstract excerpt
Mutational activation of the neu (erbB-2) receptor protein tyrosine kinase gene appears to be the triggering event in the process of oncogenesis induced by N-ethyl-N-nitrosourea (EtNU) in immature Schwann cells of the rat peripheral nervous system. Subsequent loss of the wild-type neu allele may...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Transformation, Neoplastic
- Ethylnitrosourea
- Gene Expression Regulation, Developmental
- Genes, erbB-2
- Homozygote
- Molecular Sequence Data
- Mutation
- Neurilemmoma
- Promoter Regions, Genetic
- Rats
- Rats, Sprague-Dawley
- Schwann Cells
- Transfection
- Transgenes
- Trigeminal Nerve