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Article

Wild type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells.

Oncogene - 21 Mar 1996

Nikitin A Y, Jin J J, Papewalis J, Prokopenko S N, Pozharisski K M, Winterhager E, Flesken-Nikitin A, Rajewsky M F

Abstract excerpt

Mutational activation of the neu (erbB-2) receptor protein tyrosine kinase gene appears to be the triggering event in the process of oncogenesis induced by N-ethyl-N-nitrosourea (EtNU) in immature Schwann cells of the rat peripheral nervous system. Subsequent loss of the wild-type neu allele may represent a critical secondary step towards malignancy. Developmentally-regulated expression of a wild-type rat neu...

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PMID: 8649833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Wild type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells.PMID 8649833Read ↗

Early mutation of the neu (erbB-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage.Semantic proximity Read ↗

neu mutations and loss of normal allele in schwannomas induced by N-ethyl-N-nitrosourea in rats.Semantic proximity Read ↗

Suppression of ethylnitrosourea-induced schwannoma development involves elimination of neu/erbB-2 mutant premalignant cells in the resistant BDIV rat strain.Semantic proximity Read ↗

neu mutation in schwannomas induced transplacentally in Syrian golden hamsters by N-nitrosoethylurea: high incidence but low allelic representation.Semantic proximity Read ↗

Infrequent transforming mutations in the transmembrane domain of the neu oncogene in spontaneous rat schwannomas.Semantic proximity Read ↗

Ethylnitrosourea-induced development of malignant schwannomas in the rat: two distinct loci on chromosome of 10 involved in tumor susceptibility and oncogenesis.Semantic proximity Read ↗

neu proto-oncogene mutation is specific for the neurofibromas in a N-nitroso-N-ethylurea-induced hamster neurofibromatosis model but not for hamster melanomas and human Schwann cell tumors.Semantic proximity Read ↗

Loss of heterozygosity in malignant rat schwannomas chemically induced in hybrids of inbred rat strains with differential tumor susceptibility.Semantic proximity Read ↗

Polymorphic changes of cell phenotype caused by elevated expression of an exogenous NEU proto-oncogene.Semantic proximity Read ↗

[Polymorphic changes in cellular phenotype during hyperexpression of the NEU proto-oncogene].Semantic proximity Read ↗

Overexpression of activated neu/erbB2 initiates immortalization and malignant transformation of immature Schwann cells in vitro.Semantic proximity Read ↗

Gender-specific polygenic control of ethylnitrosourea-induced oncogenesis in the rat peripheral nervous system.Semantic proximity Read ↗

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