Article
The induction of apoptosis in human mammary luminal epithelial cells by expression of activated c-neu and its abrogation by glucocorticoids.
British journal of cancer - 1 Aug 1995
Harris R A, Hiles I D, Page M J, O'Hare M J
Abstract excerpt
The effects of expressing neu-T, a mutated constitutively activated form of c-neu, have been examined in the non-transformed conditionally immortalised human mammary luminal epithelial cell line, HB4a. A variant cell line, N4.1, which expressed neu-T, showed evidence of transformation, including...
Topics
- Apoptosis
- Breast
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Culture Media, Serum-Free
- Epithelial Cells
- Epithelium
- Gene Expression Regulation
- Genes, erbB-2
- Genetic Variation
- Glucocorticoids
- Humans
- Mutation
- Protein-Tyrosine Kinases