Polymorphic changes of cell phenotype caused by elevated expression of an exogenous NEU proto-oncogene.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Polymorphic changes of cell phenotype caused by elevated expression of an exogenous NEU proto-oncogene.

Oncogene - 1 Mar 1990

Tarakhovsky A M, Resnikov M, Zaichuk T, Tugusheva M V, Butenko Z A, Prassolov V S

Abstract excerpt

The NEU proto-oncogene encodes a 185,000 dalton transmembrane glycoprotein with extensive homology to epidermal growth factor receptor. In the current study the effect of exogenous NEU expression on phenotype and growth properties of cells established lines was examined. The replication defective retroviruses were used to express constitutively NEU cDNA in the Rat-1, NIH3T3 and Balb/c3T3 cells. In spite of the...

Topics

Animals
Cells, Cultured
Cloning, Molecular
Defective Viruses
Gene Expression
Genetic Vectors
Mice
Mice, Inbred Strains
Molecular Weight
Phenotype
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Proto-Oncogenes

Rats

Receptor, ErbB-2

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 1969137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1969137-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphic changes of cell phenotype caused by elevated expression of an exogenous NEU proto-oncogene.PMID 1969137Read ↗

[Polymorphic changes in cellular phenotype during hyperexpression of the NEU proto-oncogene].Semantic proximity Read ↗

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.Semantic proximity Read ↗

Wild type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells.Semantic proximity Read ↗

The role of non-ras transforming genes in chemical carcinogenesis.Semantic proximity Read ↗

Acquisition of a tumorigenic phenotype by a rat ventral prostate epithelial cell line expressing a transfected activated neu oncogene.Semantic proximity Read ↗

neu mutations and loss of normal allele in schwannomas induced by N-ethyl-N-nitrosourea in rats.Semantic proximity Read ↗

Oncogenic activating mutations in the neu/erbB-2 oncogene are involved in the induction of mammary tumors.Semantic proximity Read ↗

Mutation of the human neu protein facilitates down-modulation by monoclonal antibodies.Semantic proximity Read ↗

Transfection of rat ovarian surface epithelium with erb-B2/neu induces transformed phenotypes in vitro and the tumorigenic phenotype in vivo.Semantic proximity Read ↗

Amplification of the <i>neu/erbB-2</i> oncogene in a mouse model of mammary tumorigenesisSemantic proximity Read ↗

Partial reversion of transformed phenotype of B104 cancer cells by antisense nucleic acids.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.