Point mutation of the neu gene in rat neural tumor RT4-AC cells: suppression of tumorigenicity by s-Myc.

Abstract excerpt

Forced expression of the s-myc gene suppressed the tumorigenicity of rat RT4-AC tumor cells in nude mice, as reported previously. Polymerase chain reaction (PCR) analysis indicated that RT4-AC cells established from a tumor of the peripheral nervous system contain an activated neu gene with a T----A transversion in the transmembrane domain. Synthesis of a protein of 60 kd kd in RT4-AC cells was specifically...

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