Article
Point mutation of the neu gene in rat neural tumor RT4-AC cells: suppression of tumorigenicity by s-Myc.
Japanese journal of cancer research : Gann - 1 Nov 1990
Lee S Y, Sugiyama A, Sueoka N, Kuchino Y
Abstract excerpt
Forced expression of the s-myc gene suppressed the tumorigenicity of rat RT4-AC tumor cells in nude mice, as reported previously. Polymerase chain reaction (PCR) analysis indicated that RT4-AC cells established from a tumor of the peripheral nervous system contain an activated neu gene with a T--...
Topics
- Animals
- Blotting, Northern
- Cell Transformation, Neoplastic
- DNA
- Electrophoresis, Polyacrylamide Gel
- Gene Expression Regulation, Neoplastic
- Genes, myc
- Guinea Pigs
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins
- Peripheral Nervous System Neoplasms
- Polymerase Chain Reaction
- RNA
- Rats
- Sequence Homology, Nucleic Acid