Article
Analysis of full coding sequence of the TP53 gene in invasive vulvar cancers: Implications for therapy.
Gynecologic oncology - 1 Aug 2017
Kashofer Karl, Regauer Sigrid
Abstract excerpt
OBJECTIVE: This study evaluates the frequency and type of TP53 gene mutations and HPV status in 72 consecutively diagnosed primary invasive vulvar squamous cell carcinomas (SCC) during the past 5years. METHODS: DNA of formalin-fixed and paraffin embedded tumour tissue was analysed for 32 HPV subtypes and the full coding sequence of the TP53 gene, and correlated with results of p53 immunohistochemistry. RESULTS:...
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