Article
Identification of TP53 gene mutations in uterine corpus cancer with short follow-up.
Gynecologic oncology - 1 Dec 1997
Koul A, Borg A, Pejovic T, Bendahl P O, Högberg T, Iosif C S, Killander D
Abstract excerpt
The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced...
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