Article
Identification of TP53 gene mutations in uterine corpus cancer with short follow-up.
Gynecologic oncology - 1 Dec 1997
Koul A, Borg A, Pejovic T, Bendahl P O, Högberg T, Iosif C S, Killander D
Abstract excerpt
The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 non...
Topics
- Aged
- Aged, 80 and over
- Alleles
- DNA Primers
- DNA, Neoplasm
- Disease-Free Survival
- Female
- Flow Cytometry
- Follow-Up Studies
- Genes, p53
- Humans
- Middle Aged
- Mutation
- Ploidies
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Receptors, Estrogen
- Receptors, Progesterone