Article
The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways.
Cancer - 15 Feb 2000
Lax S F, Kendall B, Tashiro H, Slebos R J, Hedrick L
Abstract excerpt
BACKGROUND: The two most common types of uterine endometrial carcinoma, endometrioid (UEC) and serous (USC), differ in their histopathologic appearance and biologic behavior. Recent studies suggest that these differences may be associated with distinct molecular genetic alterations. METHODS: In the current study, the authors compared the frequencies of K-ras and p53 mutations and microsatellite instability (MI)...
Topics
- Carcinoma
- Carcinoma, Endometrioid
- Codon
- Endometrial Neoplasms
- Female
- Genes, ras
- Humans
- Immunohistochemistry
- Microsatellite Repeats
- Mutation
- Point Mutation