Pathogenetic significance of p53 and c-Ki-ras gene mutations and human papillomavirus DNA integration in adenocarcinoma of the uterine cervix and uterine isthmus.

doi:10.1002/ijc.2910590505

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Pathogenetic significance of p53 and c-Ki-ras gene mutations and human papillomavirus DNA integration in adenocarcinoma of the uterine cervix and uterine isthmus.

International journal of cancer - 1 Dec 1994

Jiko K, Tsuda H, Sato S, Hirohashi S

Abstract excerpt

The pathogenetic significance of p53 and c-Ki-ras gene mutations and genomic integration of human papillomavirus (HPV) DNA was examined in surgically resected specimens of adenocarcinomas of the uterine cervix and isthmus using polymerase chain reaction (PCR), single-strand-conformation polymorphism and Southern blotting analysis. Among 25 cervical adenocarcinomas, p53 gene mutations between exons 5 and 8 were...

Topics

Adenocarcinoma
Adult
Aged
Base Sequence
DNA, Viral
Exons
Female
Genes, p53
Genes, ras
Humans
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Papillomaviridae

Polymerase Chain Reaction

Polymorphism, Genetic

Uterine Cervical Neoplasms

Uterine Neoplasms

Source

Open in PubMed

Identifiers

PMID: 7960232
DOI: 10.1002/ijc.2910590505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7960232-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathogenetic significance of p53 and c-Ki-ras gene mutations and human papillomavirus DNA integration in adenocarcinoma of the uterine cervix and uterine isthmus.PMID 7960232Read ↗

Frequent occurrence of p53 gene mutations in uterine cancers at advanced clinical stage and with aggressive histological phenotypes.Semantic proximity Read ↗

Analysis and clinical implications of p53 gene mutations and human papillomavirus type 16 and 18 infection in primary adenocarcinoma of the uterine cervix.Semantic proximity Read ↗

The carcinogenic role of oncogenic HPV and p53 gene mutation in cervical adenocarcinomas.Semantic proximity Read ↗

K-ras activation in premalignant and malignant epithelial lesions of the human uterus.Semantic proximity Read ↗

The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways.Semantic proximity Read ↗

Correlation between human papillomavirus positivity and p53 gene overexpression in adenocarcinoma of the uterine cervix.Semantic proximity Read ↗

p53 and human papillomavirus DNA in renal pelvic and ureteral carcinoma including dysplastic lesions.Semantic proximity Read ↗

Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma.Semantic proximity Read ↗

p53 gene mutations in Barrett's epithelium and esophageal cancer.Semantic proximity Read ↗

Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma.Semantic proximity Read ↗

Abnormal expression or mutation of TP53 and HPV in vulvar cancer.Semantic proximity Read ↗

Expression of p53, p16 INK4A , pRb, p21 WAF1/CIP1 , p27 KIP1 , cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papillomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.