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Article

Homozygous inactivation of WT1 in a Wilms' tumor associated with the WAGR syndrome.

Genes, chromosomes & cancer - 1 Jul 1993

Gessler M, König A, Moore J, Qualman S, Arden K, Cavenee W, Bruns G

Abstract excerpt

Wilms' tumor is a childhood nephroblastoma that is postulated to arise through the inactivation of a tumor suppressor gene by a two-hit mechanism. A candidate 11p13 Wilms' tumor gene, WT1, has been cloned and shown to encode a zinc finger protein. Patients with the WAGR syndrome (Wilm's tumor, aniridia, genitourinary abnormalities, and mental retardation) have a high risk of developing Wilms' tumor and they carry...

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Identifiers

PMID: 7687865
DOI: 10.1002/gcc.2870070304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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WT1: a novel tumor suppressor gene inactivated in Wilms' tumor.Semantic proximity Read ↗

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An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.Semantic proximity Read ↗

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