Homozygous inactivation of WT1 in a Wilms' tumor associated with the WAGR syndrome.

doi:10.1002/gcc.2870070304

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Article

Homozygous inactivation of WT1 in a Wilms' tumor associated with the WAGR syndrome.

Genes, chromosomes & cancer - 1 Jul 1993

Gessler M, König A, Moore J, Qualman S, Arden K, Cavenee W, Bruns G

Abstract excerpt

Wilms' tumor is a childhood nephroblastoma that is postulated to arise through the inactivation of a tumor suppressor gene by a two-hit mechanism. A candidate 11p13 Wilms' tumor gene, WT1, has been cloned and shown to encode a zinc finger protein. Patients with the WAGR syndrome (Wilm's tumor, an...

Topics

Adolescent
Alleles
Amino Acid Sequence
Aniridia
Base Sequence
Chromosome Deletion
Chromosomes, Human, Pair 11
Cryptorchidism
Gene Expression
Genes, Tumor Suppressor
Heterozygote
Humans
Male
Molecular Sequence Data
Syndrome
Wilms Tumor

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