Article
Mutations in the Wilms' tumor gene WT1 in leukemias.
Blood - 15 Mar 1996
King-Underwood L, Renshaw J, Pritchard-Jones K
Abstract excerpt
The tissue-specific Wilms' tumor gene WT1 is expressed in a range of acute leukemias and hematopoietic cell lines. Using single-strand conformational polymorphism analysis, we have found mutations in the WT1 gene in 4 of 36 acute leukemias. WT1 mutations are found in 15% of cases of acute myeloid...
Topics
- Acute Disease
- Adolescent
- Adult
- Amino Acid Sequence
- Base Sequence
- Cells, Cultured
- Child
- DNA Mutational Analysis
- DNA, Neoplasm
- DNA-Binding Proteins
- Exons
- Fatal Outcome
- Female
- Genes, Wilms Tumor
- Hematopoietic Stem Cells
- Humans
- Leukemia
- Male