Article
Constitutional WT1 mutations in Wilms' tumor patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Nov 1998
Diller L, Ghahremani M, Morgan J, Grundy P, Reeves C, Breslow N, Green D, Neuberg D, Pelletier J, Li F P
Abstract excerpt
PURPOSE: Patients with Wilms' tumors (WT) who carry constitutional mutations in the WT1 gene have been described in case reports and small case series. We sought to determine the frequency of constitutional WT1 mutations in a larger cohort, and to identify clinical manifestations associated with...
Topics
- Adolescent
- Child
- Child, Preschool
- Cohort Studies
- DNA-Binding Proteins
- Female
- Germ-Line Mutation
- Humans
- Infant
- Male
- Mutation
- Odds Ratio
- Risk Factors
- Transcription Factors
- Urogenital Abnormalities
- WT1 Proteins
- Wilms Tumor