Article
The Wilms tumour (WT1) gene is mutated in a secondary leukaemia in a WAGR patient.
Human molecular genetics - 1 Sept 1994
Pritchard-Jones K, Renshaw J, King-Underwood L
Abstract excerpt
The Wilms tumour (WT1) gene was first localized through its deletion in individuals with the WAGR syndrome (Wilms tumour, aniridia, genitourinary abnormalities and mental retardation). Such individuals have a 30-50% lifetime risk of developing Wilms tumour and carry constitutional interstitial de...
Topics
- Abnormalities, Multiple
- Adult
- Amino Acid Sequence
- Aniridia
- Base Sequence
- Bone Marrow
- DNA, Neoplasm
- Female
- Gene Expression
- Genes, Wilms Tumor
- Humans
- Intellectual Disability
- Kidney Neoplasms
- Leukemia, Myelomonocytic, Acute
- Molecular Sequence Data
- Mutation
- Neoplasms, Second Primary
- Polymerase Chain Reaction