Article
Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2).
The Journal of experimental medicine - 1 Oct 1992
Ciccone E, Pende D, Viale O, Than A, Di Donato C, Orengo A M, Biassoni R, Verdiani S, Amoroso A, Moretta A
Abstract excerpt
This study was designed to identify the target molecules of the natural killer (NK) cell-mediated recognition of normal allogeneic target cells. As previously shown, the gene(s) governing the first NK-defined allospecificity (specificity 1) were found to be localized in the major histocompatibili...
Topics
- Alleles
- Antibodies, Monoclonal
- B-Lymphocytes
- Base Sequence
- Cell Line, Transformed
- Cells, Cultured
- Clone Cells
- Cytotoxicity, Immunologic
- Female
- Gene Expression
- Genes, MHC Class I
- Genetic Variation
- HLA-C Antigens