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Article

Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans.

The Journal of experimental medicine - 1 Mar 1992

Ciccone E, Pende D, Viale O, Di Donato C, Tripodi G, Orengo A M, Guardiola J, Moretta A, Moretta L

Abstract excerpt

Previous studies indicated that CD3-CD16+ natural killer (NK) cells are capable of specific alloantigen recognition. Thus, alloreactive NK clones lysed normal allogeneic target cells (phytohemagglutinin [PHA] blasts) bearing the stimulating alloantigen but did not lyse autologous cells or the majority of unrelated allogeneic cells. In this study we investigated whether NK cells isolated from single individuals...

Topics

Alleles
Chromosomes, Human, Pair 6
Clone Cells
Epitopes
Flow Cytometry
Genes, Dominant
Genes, Recessive
Haplotypes
Histocompatibility Testing
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoantigens

Killer Cells, Natural

Lymphocyte Culture Test, Mixed

Major Histocompatibility Complex

Pedigree

Source

Open in PubMed Open full text

Identifiers

PMID: 1371301
DOI: 10.1084/jem.175.3.709
PMCID: PMC2119160

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1371301-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans.PMID 1371301Read ↗

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