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Article

Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans.

The Journal of experimental medicine - 1 Mar 1992

Ciccone E, Pende D, Viale O, Di Donato C, Tripodi G, Orengo A M, Guardiola J, Moretta A, Moretta L

Abstract excerpt

Previous studies indicated that CD3-CD16+ natural killer (NK) cells are capable of specific alloantigen recognition. Thus, alloreactive NK clones lysed normal allogeneic target cells (phytohemagglutinin [PHA] blasts) bearing the stimulating alloantigen but did not lyse autologous cells or the majority of unrelated allogeneic cells. In this study we investigated whether NK cells isolated from single individuals...

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Identifiers

PMID: 1371301
DOI: 10.1084/jem.175.3.709
PMCID: PMC2119160

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Source receipt: pubmed, retrieved 7 Sept 2026.

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