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Article

Natural killer cell-mediated lysis of autologous cells modified by gene therapy.

The Journal of experimental medicine - 21 Jun 1999

Liberatore C, Capanni M, Albi N, Volpi I, Urbani E, Ruggeri L, Mencarelli A, Grignani F, Velardi A

Abstract excerpt

This study investigated the role of natural killer (NK) cells as effectors of an immune response against autologous cells modified by gene therapy. T lymphocytes were transduced with LXSN, a retroviral vector adopted for human gene therapy that carries the selectable marker gene neo, and the autologous NK response was evaluated. We found that (i) infection with LXSN makes cells susceptible to autologous NK...

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Identifiers

PMID: 10377181
DOI: 10.1084/jem.189.12.1855
PMCID: PMC2192959

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Source receipt: pubmed, retrieved 7 Sept 2026.

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